Computational ADME Scientist (BS/MS)

Description The Metabolism and Pharmacokinetics group
at Novartis Institutes for Biomedical Research
(NIBR) is looking for a highly qualified M.Sc.
level scientist in the area of computational
ADME. The successful candidate will have
responsibility for computational analysis and
modeling of pharmacokinetic data using a
variety of approaches. In addition, a
successful candidate will be expected to
interact with drug metabolism scientists in
planning and conducting appropriate
modeling efforts in support of investigations
into program-specific ADME issues.Candidates possessing an M.Sc. in
Computational Chemistry or a closely related
discipline with 5+ years of experience in in
silico modeling in the drug metabolism and
pharmacokinetics field within a
pharmaceutical or biotechnology company.
An in-depth understanding of all aspects of
computational modeling within DMPK with
special emphasis on descriptor calculation
software, multivariate modeling approaches
and application in the drug discovery setting
is required. A successful candidate must be
able to plan, conduct and interpret ADME
modeling investigations in support of drug
discovery efforts. A good working knowledge
of drug metabolism and pharmacokinetics is
required, with strong competencies in
computational modeling via PLS, RF, neural
networks or similar, as well as descriptor
calculation software. Experience with
pharmacokinetic modeling software (e.g.
WinNonLin), programming language (e.g.
C++, Java), and Linux operating systems is
highly desired. A successful candidate will
need excellent interpersonal skills,
particularly oral and written communication
skills.