Scientist – Gene Design

Intrexon Corporation is developing DNA control systems to enhance the safety and efficacy of existing and novel biological therapeutics. The company’s technology employs special genetic components and activator compounds to tightly control the delivery, targeting, activation, regulation and location of biologics. The goal of such DNA-mediated control is to improve the safety of those biologics while extending their clinical effectiveness.

The company is currently engaged in clinical and pre-clinical studies related to solid tumor cancers and other intractable diseases that must be addressed with powerful biotherapeutic strategies. Together with its partners, Intrexon is committed to improving safety and clinical outcomes through the use of controllable biotherapeutics.

POSITION SUMMARY

The Scientist will be responsible for performing detailed analysis of scientific literature in order to identify critical molecular control elements. This position will require an intimate understanding of molecular biology and biochemistry techniques as well as a creative ability for problem solving in the areas of molecular cloning, protein express, and DNA, mRNA and protein engineering.

ESSENTIAL DUTIES AND RESPONSIBILITIES

• Work within a team of experienced scientists to discover and validate genetic functional units for gene expression and protein localization in mammalian cells.
• Review, analyze and prioritize candidate genetic functional units, including important regulatory units, from the scientific and patent literature.
• Design multiple sequences for validation of candidate genetic functional units in cell-based assays.
• Assist with the design and architecting of DNA vector backbones, shuttle vectors and genetic modules.
• Perform other duties as assigned.

RESPONSIBILITY

Reports to: Director, Gene Design and Analysis

EDUCATION AND EXPERIENCE

• M.S. or Ph.D. in molecular biology, biochemistry, or related discipline.
• Two (2) to five (5) years of experience in a molecular biology or genetics lab.
• The preferred candidate will have: 1) an MS in molecular biology, biochemistry, or related discipline, 2) considerable bench work experience in molecular biology, and 3) experience in the area of experimental design with a focus on essential experimental controls
• Experience in one or more of the following: reporter analysis of gene regulatory elements, design and/or construction of protein expression vectors with a focus on the use of mammalian systems for expression and purification, experience with alternative expression systems (fungi, bacteria, insects, etc.) and expression constructs of a wide range of molecular weights.
• Familiarity with the use of bioinformatics tools for sequence management and analysis
• Experience with standard DNA and protein sequence analysis tools

DESIRED KEY COMPETENCIES

• Knowledge of and hands-on technical expertise in molecular biology, biochemistry, and cellular biology.
• Advanced skills in technical literature search and analysis.
• Demonstrate the highest ethical standards and trustworthiness.
• Ability to achieve in a milestone-driven, rapidly changing research environment.
• Ability to work collaboratively in a team environment with scientists of different backgrounds and experience levels.
• Excellent written and oral communication skills.
• Skills in work and time management under project multitasking conditions.
• Planning, organization and execution skills.

·         Ability to maintain a high degree of accuracy and attention to detail.

• Possess a high degree of personal responsibility.

To Apply

Email your resume and cover letter to [Click Here to Email Your Resumé]. Note the position title in the subject line. Intrexon is an EEO employer.  No agencies, please.  For additional information about Intrexon, visit our web site at www.dna.com