Research Associate, Target Validation and Protein Expression, Ag

Description At Agensys, we're changing tomorrow by moving oncology forward. We�ve developed a pipeline of novel therapeutic fully human monoclonal antibodies (MAbs) to treat solid tumors based on our own proprietary targets. We have discovered and validated a portfolio of clinically relevant targets in 14 different cancer types. Our pipeline includes therapeutic MAbs to multiple cancer indications that are at different stages of clinical and pre-clinical development. Our parent company, Astellas Pharma US helps us shine. Together we are the bright spot in the pharmaceutical industry � not just because of what we do, but in the way we do it. If you are looking for a company where you can change a life, make a dream come true, and light the way for a better tomorrow, this is the place for you. RESEARCH ASSOCIATE TARGET VALIDATION and PROTEIN EXPRESSIONThe qualified candidate will be responsible for supporting in vitro target validation activities. In particular, the job entails addressing the function of endogenous and ectopically expressed genes using cell based and biochemical techniques such as proliferation/survival, apoptosis, signal transduction and ligand /receptor interaction assays to identify target-specific cancer phenotypes. Characterization and functional validation of antibodies in the above-mentioned cancer relevant cell-based in vitro assays will be a major emphasis. The candidate will also be responsible for evaluation of the expression pattern of the target protein in cell models and patient tissues using Western blotting/immunoprecipitation, FACS analysis, and immunoflourescence techniques. Additionally, the candidate will be responsible for mammalian tissue culture work, provision of cell reagents to other groups, and purification of target proteins using bacterial expression systems and provision of general lab support functions.

Requirements The position requires a BS or MS in Biology or a related field with a minimum 2 years of practical experience in a research laboratory. Industry or academic experience and previous work in biochemical, cancer, immunological, cell culture and molecular biology techniques are essential. Excellent verbal and communication skills, and the ability to work both independently and in a team environment are required.